Haber was a German chemist who proposed a rule for timed inhalation exposure to a toxin. He also prepared chemical warfare agents during World War I.
Parameters for a poisonous gas:
(1) concentration of the toxin in mass per unit volume
(2) time period to breathe the gas
(concentration) * (time) = constant for a particular toxic effect
A change in the concentration of the toxin will require a change in the time of exposure to produce the same toxic effect. For example, doubling the concentration of toxin means that only half the time is required to produce the effect.
Limitations:
(1) The toxic effect has to be dose dependent.
(2) It loses meaning if the time period is very long.
(3) It loses meaning if the concentration of the toxin becomes too low.
(4) newer models are more accurate
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