The International Primary CNS Lymphoma Collaborative Group developed criteria for the therapeutic response for a patient with a primary central nervous system (CNS) lymphoma.
Parameters:
(1) imaging studies of the brain
(2) corticosteroid therapy
(3) ophthalmologic examination
(4) CSF cytology
Response categories:
(1) complete response (CR)
(2) unconfirmed complete response
(3) partial response (PR)
(4) progressive disease (PD)
(5) stable disease
|
Parameter |
Complete Response |
Unconfirmed Complete Response |
|
enhancing lesions on imaging studies |
none |
none or minimal |
|
corticosteroid therapy |
none |
no or yes |
|
ophthalmologic exam |
normal |
minor abnormality in retinal pigment epithelium OR normal |
|
CSF cytology |
negative |
negative |
|
Parameter |
Partial Response |
Progressive Disease |
|
enhancing lesions on imaging studies |
>= 50% decrease in enhancement |
>= 25% increase in enhancement OR new site |
|
corticosteroid therapy |
no or yes |
no or yes |
|
ophthalmologic exam |
minor abnormality in retinal pigment epithelium OR normal OR decrease in infiltrate |
persistent OR recurrent OR new disease |
|
CSF cytology |
persistent OR suggestive diagnosis |
recurrent OR new disease |
If none of the above patterns are matched, then the patient has stable disease.
Specialty: Hematology Oncology
