Early onset neonatal sepsis due to Group B Streptococcus (GBS) is associated with certain risk factors.


Patient selection: neonate < 7 days old


Risk factors for early onset GBS sepsis:

(1) maternal colonization with Group B Streptococcus during the pregnancy

(2) history of a sibling with neonatal invasive Group B Streptococcus infection

(3) delivery at < 37 weeks gestation

(4) prolonged rupture of the membranes (>= 18 hours)

(5) chorioamnionitis

(6) Black race

(7) low maternal serum levels of anticapsular antibodies to Group B Streptococcus

(8) young maternal age


Factors reducing the risk of early onset GBS sepsis:

(1) adequate and appropriate chemoprophylaxis


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