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Differential Diagnosis of Ground-Glass Inclusions Within Hepatocytes

Purpose:

To consider possible causes for a ground-glass appearance to the cytoplasm of hepatocytes.

Specialty:

Gastroenterology

Objective:

laboratory tests, differential diagnosis and mimics, red flags

ICD-10:

K71.9

Description:

A number of conditions can cause the cytoplasm of hepatocytes to have a "ground-glass" appearance. The cytoplasm of the hepatocytes show homogeneous areas that are weakly eosinophilic after H & E staining, sometimes with a finely granular appearance. The areas may resemble an inclusion but are actually pseudo-inclusions.

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