Description

The term "great imitator" or "great masquerader" was initially given to syphilis, but it can be applied to a number of other conditions. These should be considered in situations when making a diagnosis is difficult.


 

Features of a great imitator:

(1) may be associated with many conditions

(2) may be mistaken for many other disorders

(3) common enough to be encountered with some frequency (not very rare)

 

Conditions considered great imitators:

(1) syphilis

(2) tuberculosis

(3) deep fungal infections (Coccidioidomycosis, Histoplasmosis, etc)

(4) sarcoidosis

(5) systemic lupus erythematosus (SLE)

(6) paraneoplastic disorders (as a group)

(7) celiac disease

(8) masked depression and/or post-traumatic stress disorder (PTSD)

(9) unrecognized HIV disease

 

Possible conditions that may be imitators:

(1) neuroborelliosis

(2) enteric bacterial infections (Salmonella, Yersinia, etc)

(3) masked alcoholism or substance abuse

(4) hypothyroidism

(5) Addison's disease

 


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