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Description

Parham et al graded pediatric nonrhabdomyosarcomatous soft tissue sarcomas (NRSTS). The authors are from St. Jude Children's Research Hospital in Memphis and the Pediatric Oncology Group (POGS).


 

Grade 1 tumors:

(1) myxoid liposarcoma

(2) well-differentiated liposarcoma

(3) well-differentiated fibrosarcoma

(4) infantile (<= 4 years of age) fibrosarcoma

(5) well-differentiated hemangiopericytoma

(6) infantile (<= 4 years of age) hemangiopericytoma

(7) well-differentiated malignant peripheral nerve sheath tumor (MPNST)

(8) angiomatoid malignant fibrous histocytoma (MFH)

(9) deep-seated dermatofibrosarcoma protuberans

(10) myxoid chondrosarcoma

 

Grade 3 tumors:

(1) (NOT Grade 1) AND (necrosis > 15% AND/OR mitotic rate >= 5 per 10 high power fields)

(2) one of the following:

(2a) pleomorphic liposarcoma

(2b) round-cell liposarcoma

(2c) extraskeletal osteogenic sarcoma

(2d) malignant triton tumor

(2e) alveolar soft part sarcoma

 

where:

• The high power field is using a 40x objective.

• Angiomatoid MFH and deep-seated dermatofbirosarcoma protuberans are currently considered to be obsolete terms.

 

Grade 2 tumors: (NOT Grade 1) AND NOT (Grade 3)

 

An apparent Grade 2 tumor that is markedly cellular or which shows marked nuclear atypia may be a Grade 3 tumor.

 


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