Description

Khoury et al developed a grading system for nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) in pediatric patients. The authors are from St. Jude Children's Research Hospital, Vanderbilt University, University of Tennessee, University of Nebraska and the University of Oklahoma.


 

Parameters:

(1) mitotic count in 10 high-power (40x objective) fields

(2) specific type of tumor

 

A tumor was classified as high grade if one or more of the following was present:

(1) mitotic count was >= 10 mitotic figures in 10 high-power fields

(2) pleomorphic liposarcoma

(3) round cell liposarcoma

(4) mesenchymal chondrosarcoma

(5) extraskeletal osteosarcoma

(6) alveolar soft part sarcoma

 

A tumor was classified as low grade if:

(1) mitotic count < 10 mitotic figures in 10 high-power fields

(2) well-differentiated fibrosarcoma

(3) infantile fibrosarcoma (with age <= 4 years)

 

Both tumors show a rapid decline in event-free suvival over the first 2 years then stabilize. At 5 years the event-free survival was 63% for low-grade and 13% for high-grade tumors respectively.

 


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