Okamura et al developed a grading scheme for patients with primary chronic myelofibrosis. The authors are from Kyushu University and Tokyo Women's Medical College in Japan.
Parameters:
(1) hemoglobin in g/dL
(2) percent blasts in the peripheral blood
(3) platelet count per µL
|
Parameter |
Finding |
Points |
|
hemoglobin |
>= 10 g/dL |
0 |
|
|
6 to 9.9 g/dL |
1 |
|
|
< 6 g/dL |
2 |
|
percent blasts |
< 3% |
0 |
|
|
3 to 4.9% |
1 |
|
|
>= 5% |
2 |
|
platelet count |
>= 100,000 per µL |
0 |
|
|
30,000 to 99,999 per µL |
1 |
|
|
< 30,000 per µL |
2 |
where:
• Some of the breakpoints used are similar to those used in other grading schemes above.
|
Number of Parameters with 2 Points |
Number of Parameters with 1 Point |
Grade |
|
>= 1 |
NA |
3 |
|
0 |
2 or 3 |
3 |
|
0 |
1 |
2 |
|
0 |
0 |
1 |
Over the first 15 years the curves for the 3 grades are separate. After this Grades 1 and 2 tend to merge at around 40% overall survival.
|
Grade |
Survival at 10 Years |
|
1 |
60% |
|
2 |
47% |
|
3 |
30% |
from Figure 4 page 197
Specialty: Hematology Oncology
ICD-10: ,
