Both Mycosis Fungoides and Sezary Syndrome are T-cell lymphomas with cutaneous deposits that may involve lymph nodes. The extent of lymph node involvement can be determined on histologic examination.
General features:
(1) dermatopathic lymphadenopathy (expansion of paracortical zone with dendritic cells, macrophages with or without melanin, lymphocytes, plasma cells, and variable numbers of eosinophils)
(2) number of T-cells with cerebriform (convoluted) nuclei
(3) effacement of nodal architecture
Dermatopathic Lymphadenopathy
Malignant T-Cells
Nodal Architecture
Grade
variable
none
normal
LN-0
present
occasional, without clusters
normal
LN-1
present
small clusters
normal
LN-2
variable
numerous, may be in large clusters
may be partial effacement
LN-3
variable
numerous, diffuse
partial to complete effacement
LN-4
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