The extent of disease (EOD) of metastatic tumor involving bone can be graded based on the number of lesions and extent of disease. Patients with a high extent of disease have a poor prognosis and may benefit from more aggressive therapy.
Finding
EOD Grade
normal or abnormal due to benign bone disease
0
number of bony metastases < 6
1
number of bone metastases 6 - 20
2
number of bone metastases > 20 but less than Grade 4
3
>75% of ribs, vertebrae and pelvic bone involved ("super scan")
4
Size of Metastasis
Count
< 50% of a vertrebral body
as 1 lesion
about the size of 1 vertebral body
as 2 lesions
>= 50% but < 95% of a vertebral body
not stated (? 1.5 lesions)
The greater the extent of disease, the poorer the prognosis.
EOD Grade
2 Year Survival Rate in Patients with Metastatic Prostate Cancer
1
94%
2
74%
3
68%
4
40%
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