Goode et al identified histologic criteria for grading mucoepidermoid carcinoma arising in a salivary gland. The authors are from the Armed Forces Institute of Pathology (AFIP) in Washington, D.C.
Parameters:
(1) percent intracystic component
(2) neural invasion
(3) necrosis
(4) mitotic activity
(5) anaplasia
|
Parameter |
Finding |
Points |
|
percent intracystic component |
< 20% |
2 |
|
|
>= 20% |
0 |
|
neural invasion |
present |
3 |
|
|
absent |
0 |
|
necrosis |
present |
3 |
|
|
absent |
0 |
|
mitotic activity |
> 4 mitoses in 10 high powered fields (HPF) |
3 |
|
|
<= 4 mitoses in 10 HPF |
0 |
|
anaplasia |
present |
4 |
|
|
absent |
0 |
where:
• A high power field uses a 40x objective lens.
• Brandwein et al use 25% for the intracystic component.
histologic score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 15
• A high score is associated with a poorly differentiated tumor.
|
Score |
Grade |
|
0 to 4 |
Grade I |
|
5 or 6 |
Grade II |
|
>= 7 |
Grade III |
Performance:
• The system shows good reproducibility but has a tendency to downgrade the carcinoma.
Specialty: Hematology Oncology, Surgery, general, Otolaryngology
