Rubbin-Brandt et al graded the severity of sinusoidal dilatation in patients with chemotherapy-associated sinusoidal dilatation. The authors are from University Hospital Geneva and Hopital Cochin in Paris.
Sinusoidal Dilatation in the Hepatic Lobule
Term
Grade
none
absent
0
centrilobular, inner third around the central vein
mild
1
inner two thirds around the central vein
moderate
2
panlobular
severe
3
The hepatic lobule is classically divided into 3 zones:
(1) centrilobular
(2) midzonal
(3) peripheral or periportal
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