Differential Diagnosis of Goodpasture's Syndrome

• necrotizing nasal or oral inflammation with granulomatous vasculitis?

• systemic vasculitis?

• asthma, eosinophilia, and paranasal sinus diseas?

• palpable purpura, arthritis, and abdominal pain with acute GI hemorrhage?

• microangiopathic hemolytic disease?

• oral and genital aphthous ulcers, uveitis and skin lesions?

• recent history of D-penicillamine therapy?

• history of renal disease with signs of congestive heart failure?

• pneumonia with renal failure?

• nephrotic level proteinuria?

• antibodies to glomerular basement membrane (anti-GBM)?

• p-ANCA?

• c-ANCA?

• cryoglobulins?

• high titer of Rheumatoid factor (RF)?

• high titers of antinuclear antibodies (ANA)?