Lamarca et al reported the GI-NEC score for evaluating patients with high-grade gastrointestinal neuroendocrine carcinoma. This can help to distinguish 2 prognostic groups. The authors are from The Christie NHS Foundation Trust, University of Lyon, Charite University Medicine Berlin, Cliniques Universitaires Saint-Luc Bruxelles, Doce de Octubre University Hospital, Royal Free Hospital, and the University of Manchester.
Patient selection: high-grade gastrointestinal neuroendocrine carcinoma, with Ki-67 > 20%
Exclusion: ECOG 4 and mixed adeno-neuroendocrine carcinoma