GI-NEC Score of Lamarca et al for High-Grade Gastrointestinal Neuroendocrine Carcinoma

Description

Lamarca et al reported the GI-NEC score for evaluating patients with high-grade gastrointestinal neuroendocrine carcinoma. This can help to distinguish 2 prognostic groups. The authors are from The Christie NHS Foundation Trust, University of Lyon, Charite University Medicine Berlin, Cliniques Universitaires Saint-Luc Bruxelles, Doce de Octubre University Hospital, Royal Free Hospital, and the University of Manchester.

Patient selection: high-grade gastrointestinal neuroendocrine carcinoma, with Ki-67 > 20%

Exclusion: ECOG 4 and mixed adeno-neuroendocrine carcinoma

Sites: esophagus, stomach, duodenum, appendix, colon, rectum, pancreas

Parameters:

(1) liver metastases

(2) serum alkaline phosphatase in IU/L

(3) serum LDH in IU/L

(4) ECOG performance status

(5) Ki67 in percent

Parameter	Finding	Points
liver metastases	absent	0
	present	1
serum alkaline phosphatase	<= 82	0
	83 to 289	1
	>= 290	2
serum LDH	<= 827	0
	> 827	1
ECOG performance	0 or 1	0
	2 or 3 (4 excluded)	1
Ki67	<= 80%	0
	> 80%	1

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 6

Total Score	Prognosis	Median Overall Survival
0 to 2	good	19.4 months
3 to 6	poor	5.2 months

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GI-NEC Score of Lamarca et al for High-Grade Gastrointestinal Neuroendocrine Carcinoma

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