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Genotype Resistance Index (GRI) and Genotype Failure Index (GFI) for Epidemiologic Studies of Drug Resistant Plasmodium falciparum

Specialty:

Infectious Diseases
Clinical Pharmacology

Objective:

ICD-10:

Description:

Certain genotypes of Plasmodium falciparum are associated with drug resistance, which in turn is associated with therapeutic failure in patients. The Genotype Resistance and Failure Indices (GRI, GFI) can be helpful in epidemiologic studies of drug resistance in a population. The change in drug resistance and therapeutic failure should change with changes in the prevalence of the molecular marker in malarial isolates.

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