Chronic Granulomatous Disease (CGD) is associated with a number of possible genetic mutations.
Cell function compromised in CGFD: phagocyte NADPH oxidase
Autosomal recessive inheritance:
(1) CYBA (16q24.2): cytochrome b-245 light chain
(2) CYBC1 (17q25.3): cytochrome b-245 chaperone 1
(3) NCF1 (7q11.23): neutrophil cytosol factor 1
(4) NCF2 (1q25.1): neutrophil cytosol factor 2
(5) NCF4 (22.q12.3): neutrophil cytosol factor 4
X-linked inheritance:
(1) CYBB (Xp12.1-p11.4): cytochrome b-245 heavy chain
