Gene Expression Patterns of Sorlie et al for Breast Carcinoma

Pattern

Features

luminal A

strong luminal cell gene expression including strong ER

luminal B

low to moderate luminal cell gene expression including ER

luminal C

low to moderate luminal cell gene expression including ER, high expression of novel set of genes seen also in basal cell and ERBB2 subtypes

normal breast-like

expresses genes seen in adipose and nonepithelial tissue, low to absent ER and luminal genes, strong basal epithelial genes

ERRB2+ (HER2 +)

HER2 positive, low to absent ER and luminal genes

basal cell-like

basal cell genes, low to absent ER and luminal genes, CK5 and CK17, laminin, FABP7

Pattern

5-Year Overall Survival

luminal A

90%

luminal B

49%

luminal C

42%

normal breast

52%

ERRB2+ (HER2 +)

30%

basal cell

0%