Gastric amyloidosis is an uncommon condition whose endoscopic appearance may mimic other conditions. It may be part of systemic amyloidosis or rarely primary to the stomach.
Clinical presentations include:
(1) GI bleeding
(2) epigastric pain
(3) nausea and vomiting
(4) gastritis
The endoscopic appearance may mimic:
(1) chronic gastritis
(2) peptic ulcer
(3) gastric cancer
(4) gastrointestinal stromal tumor (GIST)
(5) MALT lymphoma
The diagnosis depends on identifying extracellular amyloid in a biopsy specimen.
Endoscopic ultrasound can suggest the diagnosis by showing thickened, hypoechoic gastric walls.
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