Fragile X-Associated Primary Ovarian Insufficiency (POI) is relatively common but often goes unrecognized.
(1) ovarian dysfunction including decreased fertility
(2) onset of menopause when < 40 years of age
(3) family history of premature menopause or ovarian failure
(1) The woman is a permuation carrier with 1 FMR1 allele that has 55 to 200 CGG repeats.
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