Thomas et al developed an equation for predicting renal clearance of carboplatin that uses 5 variables including cystatin C. The authors are from the Institut Claudius-Regaud in Toulouse, France.
Parameters:
(1) age in years
(2) gender
(3) body weight in kilograms
(4) serum creatinine in µmol/L
(5) serum cystatin C in mg/L
A = ((serum creatinine) / 75)^(-0.512)
B = (serum cystatin C)^(-0.327)
C = ((body weight) / 65)^(0.474)
D = ((age) / 56)^(-0.387)
E = 1 if male or 0.854 if female
renal clearance of carboplatin in mL per minute =
= 110 * A * B * C * D * E
NOTE: The clearance is not adjusted for body surface area (BSA).
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