Keys developed an equation for calculating the oncotic pressure in serum associated with serum proteins.
Parameters:
(1) serum albumin concentration in g/dL
(2) serum total globulin concentration in g/dL
(3) temperature in °K (°C + 273.16)
(4) factor
Total Protein in g/dL
Factor
1
0.88
2
0.92
3
0.98
4
1.03
5
1.09
6
1.17
7
1.28
8
1.45
This can be approximated as:
Total Protein
Value of f
1 to 4
(0.002143 * ((protein)^2)) + (0.04014 * (protein)) + 0.836
4 to 8
(0.01786 * ((protein)^2)) - (0.1113 * (protein)) + 1.193
oncotic pressure in mm H2O =
= (factor) * ((45.2 * (albumin concentration)) + (18.86 * (globulin concentration)) * (temperature) / 273.16
Interpretation:
• The normal oncotic pressure is 28 to 48 cm water (20.6 to 35.3 mm Hg)
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Purpose: To calculate the serum oncotic pressure using the equation of Keys.
Specialty: Endocrinology, Clinical Laboratory
Objective: laboratory tests, other testing
ICD-10: R77,
