Chen et al reported the Flu-IV score for predicting invasive mechanical ventilation for a patient with influenza pneumonia. The authors are from Nanjing Lishui People's Hospital, Beijing Jishuitan Hospital, 4th Medical College of Peking University, and multiple affiliated hospitals.
Flu-IV = influenza invasive ventilation
Parameters:
(1) early neuraminidase inhibitor (NAI) therapy
(2) multilobar infiltrate
(3) absolute lymphocyte count in 10^9/L
(4) use of systemic corticosteroids
(5) age in years
(6) PaO2 to FIO2 ratio
(7) respiratory rate in breaths per minute
(8) arterial pH
Parameter
Finding
Points
early NAI therapy
no
0
yes
-3
multilobar infiltrate
no
0
yes
1
absolute lymphocyte count
>= 0.8 * 10^9/L
0
< 0.8 * 10^9/L
1
systemic corticosteroids
no
0
yes
1
age in years
< 65 years
0
>= 65 years
1
PaO2 to FIO2 ratio
>= 300
0
< 300
2
respiratory rate
<= 30 breaths per minute
0
> 30 breaths per minute
3
arterial pH
>= 7.35
0
< 7.35
4
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -3
• maximum score: 13
• A score >= 5 was associated with invasive mechanical ventilation.
Performance:
• The area under the ROC curve is 0.91.
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