The DNA index reflects the DNA content of a tumor cell population relative to that of normal cells.
DNA index =
= (relative DNA of tumor cell peak) / (relative DNA content of normal, diploid cells)
Interpretation:
• normal cells contain twice the haploid content of DNA and are termed diploid
• an abnormal, non-diploid DNA content is termed aneuploid
• if the tumor cells contain less DNA than diploid cells, they are termed hypoploid
• if the tumor cells contain more DNA than diploid cells, they are termed hyperploid
• if the tumor has twice the DNA of a diploid cell, then it is termed tetraploid
• if the tumor has four times the DNA of a diploid cell, then it is termed octaploid
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Specialty: Hematology Oncology, Surgery, general, Clinical Laboratory
