Kohnke et al reported a score using flow cytometry diagnosis to make the diagnosis of chroonic lymphocytic leukemia. This is more specific than the Matutes score. The authros are from the Univeristy of Munich.
Parameters:
(1) percent CD200 positive cells
(2) percent positive for both CD5 and CD23
(3) percent CD79b positive
(4) percent FMC7 positive
CLL flow score =
= (percent CD200 positive) + (percent positive for both CD5 and CD23) - (percent positive for CD79b) - (percent positive for FMC7)
Interpretation:
• minimum score: -200
• maximum score: 200
• The higher the score the greater the likelihood of CLL.
• A score > 0 indicates CLL.
Performance:
• The area under the ROC curve is 0.98.
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