Lian et al reported the FLAIR prognostic model for amyopathic dermatomyositis with interstitial lung disease (ADM-ILD). The authors are from Shanghai Jiaotong University.
Patient selection: amyopathic dermatomyositis-associated interstitial lung disease (ADM-ILD)
Parameters:
(1) rapidly progressive interstitial lung disease
(2) high resolution lung CT (HRCT) score based on Ichikado et al
(3) anti-MDA5 antibody (antimelanoma differentiation-associated gene 5)
(4) serum ferritin in ng/mL
(5) serum LDH in U/L
Parameter
Finding
Points
interstitial lung disease
not rapidly progressive
0
rapidly progressive
2
HRCT score
< 133
0
>= 133
3
anti-MDA5 antibody
negative
0
1+
2
2+
3
3+
4
serum ferritin
< 636 ng/mL
0
>= 636 ng/mL
2
serum LDH
< 355 U/L
0
>= 355 U/L
2
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 13
Score
Risk Group
1-Year Survival
0 to 4
low
100%
5 to 9
medium
84-92%
10 to 13
high
15-34%
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