A patient with a personal history of breast cancer can be identified as having a genetic risk for breast cancer if certain findings are present.
Parameters to consider:
(1) features of breast cancer
(2) personal history and/or family history
Indicators of a genetic risk for cancer based personal features with one or more of the following:
(1) someone in family with a known mutation for a cancer susceptibility gene
(2)breast cancer diagnosed <= 50 years of age
(3) triple negative (ER, PR, HER2) breast cancer diagnosed <= 60 years of age
(4) >= 2 primary breast cancers
(5) >= 1 close blood relative with breast cancer diagnosed <= 50 years of age
(6) >= 1 close blood relative with invasive ovarian cancer
(7) >= 2 close blood relatives with breast cancer, aggressive prostate cancer or pancreatic cancer
(8) personal history pancreatic cancer
(9)Ashkenazi Jewish descent with cancer of the ovary, fallopian tube or pancreas
(10) being male
(11) manifestations of Cowden syndrome (skin lesions, macrocephaly, hamartomatous polyps of the GI tract)
Indicators of a genetic risk for cancer based on personal and/or family history for cancer - with >=3 of the following, especially if diagnosed when <= 50 years of age:
(1) breast
(2) pancreas
(3) prostate (with Gleason score >= 7 or metastatic)
(4) melanoma
(5) sarcoma
(6) adrenal cortex
(7) brain
(8) leukemia
(9) diffuse gastric
(10) colon
(11) endometrium
(12) thyroid
(13) kidney
