A patient with no personal history of cancer can be identified as having a genetic risk for breast cancer if certain findings are present.
Parameters to consider:
(1) history in a close relative
(2) family cancer history
Indicators of a genetic risk for cancer based on a close relative with one or more of the following:
(1) a known mutation for a cancer susceptibility gene
(2)breast cancer diagnosed <= 45 years of age
(3) >= 2 primary breast cancers
(4)a primary cancer of the ovary, fallopian tube or peritoneum
(5) breast cancer AND male
(6) manifestations of Cowden syndrome (skin lesions, macrocephaly, hamartomatous polyps of the GI tract)
Indicators of a genetic risk for cancer based on family history for cancer - with >=3 of the following, especially if diagnosed when <= 50 years of age:
(1) breast
(2) pancreas
(3) prostate (with Gleason score >= 7 or metastatic)
(4) melanoma
(5) sarcoma
(6) adrenal cortex
(7) brain
(8) leukemia
(9) diffuse gastric
(10) colon
(11) endometrium
(12) thyroid
(13) kidney
