Description

Botulinum toxin can be used as a biological weapon. An outbreak of botulism should prompt notification of authorities and an investigation for the source and cause, especially when a dietary source has not been identified.


 

Situations suggesting release of botulinum toxin as a biological weapon:

(1) Outbreak of acute flaccid paralysis with prominent bulbar palsies (diplopia, dysarthria, dysphonia, dysphagia) in patients who are afebrile and with a clear sensorium.

(2) Outbreak with an unusual botulinum toxin

(2a) type C, D, F, or G

(2b) type E not acquired from an aquatic food

(3) Outbreak with a common geographic factor or activity among cases

(3a) with features favoring an aerosol attack

(3b) common dietary exposure under suspicious circumstances

(4) Multiple simultaneous outbreaks without a common identifiable source.

 

A patient with symptoms compatible with botulism should have a complete history and physical, with emphasis placed on:

(1) dietary history

(2) travel and activity history

(3) other persons with similar symptoms

 


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