If a series of diagnostic tests are performed, then the individual test performance characteristics can be used to calculate the final post-test probability.



(1) initial pre-test probability (typically the prevalence of the condition in the population)

(2) sensitivity and specificity for each test


The post-test probability for the first test is used as the pre-test probability for the second and so on until all of the testing is complete.


For the implementation the assumption is that all of the tests had positive results.


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