Description

Tavaglione et al reported a the Fibrotic NASH Index (FNI) to screen for fibrotic nonalcoholic steatohepatitis (NASH). These can help to identify a patient who should be a more extensive workup. The authors are from multiple institutions in Italy, Sweden, Finland, and the United States.


Patient selection: high risk for NASH (obese, type 2 diabetes and metabolic syndrome)

 

Parameters:

(1) serum AST in U/L

(2) hemoglobin A1c in percent

(3) serum HDL cholesterol in mg/dL

 

Parameter

Points

serum AST

2.54 * LN(AST)

hemoglobin A1c

3.86 * LN(HgbA1c)

serum HDL cholesterol

-1.66 * LN(HDL)

 

value of X =

= SUM(points for all of the parameters) - 10.33

 

probability of fibrotic HASH =

= 1 / (1 + EXP((-1) * X))

 

Performance:

• The area under the ROC curve was 0.78.


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