Wu et al reported the Fibrostage score for evaluating a patient with chronic hepatitis B (HBV). This can help to identify a patient with significant fibrosis. The authors are from Zhejiang University in Hangzhou, China.
Patient selection: chronic HBV
Parameters:
(1) serum FT4 in pmol/L
(2) serum GGT in IU/L
(3) serum cholinesterase in U/L
(4) platelet count in 10^9/L
(5) age in years
Parameters
Points
serum FT4
-3.9*LN(FT4)
serum GGT
0.9 * LN(GGT)
serum cholinesterase
-2.6 * LN(cholinesterase)
platelet count
-LN(platelet count)
years
2.5*LN(age)
total score =
= SUM(points for all 4 parameters) + 24.6
Fibrostage
Fibrosis
< -3.2
absent
< -2.5
excludes advanced fibrosis
> -1.3
significant fibrosis
> -0.4
advanced fibrosis
> 0.9
predicts cirrhosis
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