Koda et al reported the FibroIndex for detection of a patient with significant fibrosis associated with chronic hepatitis C. The score may help to reduce the number of liver biopsies required for patient evaluation. The authors are from Tottori University and San-in Rosai Hospital in Yonago, Japan.
Patient selection: chronic HCV infection
Parameters:
(1) platelet count per microliter
(2) serum AST in IU/L
(3) gamma globulin in g/dL
Parameter
Points
platelet count
0.064 * ((PC) / (10^4))
serum AST
0.005 * (AST)
gamma globulin
0.463 * (gamma globulins)
FibroIndex =
= SUM(points for all 3 parameters)
FibroIndex
Significant Fibrosis
<= 1.25
unlikely
1.26 to 2.24
possible
>= 2.25
probable
Performance:
• The area under the ROC index for identifying significant fibrosis was 0.83.
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