Description

The FIB-8 Index is an extension of the FIB-4 score and is a noninvasive score that can help to identify a patient with significant hepatic fibrosis.


Parameters:

(1) FIB-4 score of Sterling et al based on age, serum AST, platelet count and serum ALT, typically in range from 0 to 5

(2) body mass index in kg per square meter

(3) albumin to globulin ratio

(4) serum GGT in U/L

(5) diabetes

 

Parameters

Finding

Points

FIB-4 score

 

(FIB-4 score)

body mass index

 

0.025 * (BMI)

albumin to globulin ratio

 

-0.702 * (ratio)

serum GGT

 

0.004 * (GGT)

diabetes

no

0

 

yes

0.858

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• The low cutoff for >= F2 fibrosis is 0.88 and the high cutoff is 1.77.

• In Prasoppokakorn et al a score from 1,1 to 2.4 was seen in F0-1 and 2.2 to 4.0 in >=F2.

 

Performance:

• The area under the ROC curve is 0.77.


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