Hoogeveen et al estimated the fetoplacental blood volume using the change in fetal hemoglobin following intrauterine blood transfusion. The authors are from Leiden University in The Netherlands.
Method: The intrauterine blood transfusion was performed using the umbilical vein. Blood was sampled before and after transfusion of donor blood.
fetoplacental red cell volume before transfusion in mL =
= (volume of donor blood transfused in mL) * (donor hematocrit as decimal fraction) * (percent hemoglobin F after transfusion) / ((percent fetal hemoglobin F before transfusion) - (percent hemoglobin F after transfusion))
• The percent hemoglobin F can be expressed as either a decimal fraction or whole number.
fetoplacental blood volume in mL before transfusion =
= (fetoplacental red cell volume before transfusion in mL) / (fetal pretransfusion hematocrit as a decimal fraction)
The authors also estimated the fetoplacental blood volume from gestational age:
estimated fetoplacental blood volume in mL =
= (15.10 * (gestational age in weeks)) - 279
• The r value is 0.85
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Purpose: To estimate the fetoplacental blood volume based on changes in fetal hemoglobin before and after intra-uterine transfusion using the method of Hoogeveen et al.
ICD-10: P55, P61,