The Renal Fanconi Syndrome (RFS) may be caused by a wide variety of causes that affect the function of the proximal renal tubule.
Synonym: Lignac-de Toni-Debre-Fanconi Syndrome
RFS consists of:
(1) a generalized dysfunction of the proximal renal tubule with wastage of water, electrolytes, and other compounds
(2) vitamin-D resistant metabolic bone disease
Compounds lost in the urine include:
(13) low molecular weight (LMW) serum proteins including immunoglobulin light chain
(14) amino acids
(1) polyuria with polydipsia
(5) bone disease
(5a) rickets with impaired growth in a pediatric patient
(5b) osteomalacia in an adult
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Specialty: Nephrology, Clinical Laboratory