Aplastic anemia and myelodysplastic features can both show pancytopenia and other overlapping features. Iwasaki et al reported findings that can help to distinguish between these two conditions. The authors are from Nagoya University, Chubu University and Nagoya First Hospital in Japan.
Patient selection: aplastic anemia vs myelodysplastic syndrome with refractory anemia
Analysis:
(1) immunostaining for p53
(2) immunostaining for hemoglobin F in erythroblasts
(3) karyotype analysis
Analysis
Aplastic Anemia
Myelodysplasia
p53
negative
positive in about 70%
percent hemoglobin F
negative in 82%
positive
chromosomal abnormality
negative
positive
47 of 48 patients with MDS had at least one abnormal marker.
High risk MDS tended to have greater aberrations.
This battery cannot distinguish between all cases.
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