Jeon et al evaluated patients with extensively drug-resistant tuberculosis in South Korea. The authors are from Harvard University, National Institutes of Health, Yonsei University, and the National Masan Tuberculosis Hospital.


Findings in patients with extensively drug-resistant strains:

(1) prolonged cumulative therapy (usually multiple regimens), typically > 18 months

(2) prior therapy with second line drugs

(3) positive sputum culture at 6 months after starting therapy


Initial antibiotic resistance patterns seen with the extensively drug-resistant strains:

(1) resistance to kanamycin

(2) resistance to ofloxacin (fluoroquinolone resistance)


A patient presenting with one or more of these findings should be suspected of having an extensively drug-resistant strain.


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