NOTE: A patient who meets the clinical criteria (vascular thromboses and/or pregnancy morbidity) for the antiphospholipid syndrome is excluded from the definition.
Features:
(1) laboratory features of the antiphospholipid syndrome, with the presence of:
(1a) lupus anticoagulant
(1b) anticardiolipin antibody
(1c) anti-beta-glycoprotein I antibody
(1d) mixture of 2 or more types
(2) presence of thrombocytopenia (platelet count < 100,000 per µL) on at least 2 measurements at least 12 weeks apart
(3) exclusion another explanation for thrombocytopenia including:
(3a) disseminated intravascular coagulopathy (DIC)
(3b) thrombotic thrombocytopenic purpura (TTP)
(3c) hemolytic uremic syndrome (HUS)
(3d) heparin-induced thrombocytopenia
(3e) pseudothrombocytopenia
Additional descriptors:
(1) presence or absence of SLE
(2) severity
|
Platelet Count per µL
|
Severity
|
|
50,000 - 99,999
|
moderate
|
|
< 50,000
|
severe
|
where:
• Mild thrombocytopenia (levels >= 100,000 per µL) is not included in the definition.
• Severity descriptions is meaningful if the platelet counts are relatively stable.
