An international consensus committee described features for the antiphospholipid syndrome and related conditions. One of the related conditions is persistent thrombocytopenia.
NOTE: A patient who meets the clinical criteria (vascular thromboses and/or pregnancy morbidity) for the antiphospholipid syndrome is excluded from the definition.
(1) laboratory features of the antiphospholipid syndrome, with the presence of:
(1a) lupus anticoagulant
(1b) anticardiolipin antibody
(1c) anti-beta-glycoprotein I antibody
(1d) mixture of 2 or more types
(2) presence of thrombocytopenia (platelet count < 100,000 per µL) on at least 2 measurements at least 12 weeks apart
(3) exclusion another explanation for thrombocytopenia including:
(3a) disseminated intravascular coagulopathy (DIC)
(3b) thrombotic thrombocytopenic purpura (TTP)
(3c) hemolytic uremic syndrome (HUS)
(3d) heparin-induced thrombocytopenia
(1) presence or absence of SLE
Platelet Count per µL
50,000 - 99,999
• Mild thrombocytopenia (levels >= 100,000 per µL) is not included in the definition.
• Severity descriptions is meaningful if the platelet counts are relatively stable.
To read more or access our algorithms and calculators, please log in or register.
Specialty: Hematology Oncology, Clinical Laboratory, Immunology/Rheumatology