Pulmonary involvement in the Birt-Hogg-Dube syndrome may be difficult to differentiate from lymphangioleiomyomatosis (LAM).
(2) size and shape
(3) epithelial lining
(4) smooth muscle infiltration
(5) relationships to pulmonary vessels
(6) relationship to pleura
(7) immunostaining with HMB-45 (indicating melanogenesis)
basilar, peripheral or subpleural
smooth muscle infiltration
relationship with pulmonary vessels
abut proximal arteries and veins
relatationship to pleura
may abut pleural surface
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