Features of familial myeloma:
(1) plasma cell disorder(s)
(2) involves first-degree relatives
(3) susceptibility to other neoplasms
Plasma cell disorders may include:
(1) myeloma
(2) MGUS (monoclonal gammopathy of uncertain significance)
(3) amyloidosis
A plasma cell neoplasm should be evaluated for chromosomal abnormalities. Patients and family members should be tested for serum light chains.
Neoplasms associated with familial myeloma:
(1) non-Hodgkin’s lymphoma
(2) Hodgkin’s lymphoma
(3) chronic lymphocytic leukemia (CLL)
(4) myeloproliferative disorder
(5) prostate or female genital cancer
(6) breast cancer
(7) gastrointestinal carcinoma
(8) melanoma
(9) other
Differential diagnosis:
(1) amyloidosis associated with hereditary inflammatory disorder
