The Familial HCG Syndrome is a rare hereditary condition.



(1) Men and women in a family have persistently positive immunoassays for hCG

(2) The positive test result cannot be explained by pregnancy, tumor, dietary intake or administration of hCG.

(3) Family members have circulating hCG degradation products.

(4) Family members are asymptomatic.


Circulating hCG degradation products:

(1) hCG-beta

(2) hCG missing the beta subunit C-terminal peptide

(3) hCG beta lacking the C-terminal peptide


Males may go undetected since hCG testing is not commonly done on men.


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