A laboratory test that uses latex particles may show a falsely elevated resulted in patients with a monoclonal gammopathy.
Mechanism: The paraprotein coats the latex particles, causing them to aggregate.
Features of the interference:
(1) The patient has a monoclonal protein.
(2) A laboratory test that uses latex particles is positive or shows an elevated value.
(3) A repeat test shows a much lower value if (a) the paraprotein is removed or (b) a method is used that does not have latex particles.
Tests affected may include: C-reactive protein (CRP), serum ferritin, anti-streptolysin O titer
If removal of the paraprotein is used, it is important that the method used does not remove the target analyte.
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Specialty: Clinical Laboratory, Obstetrics & Gynecology, Cardiology, Emergency Medicine, Critical Care
ICD-10: ,
