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False Elevations in Inorganic Phosphate (Pseudohyperphosphatemia) Measured by the Ammonium Molybdate Method in Patients with Paraproteinemia

Specialty:

Clinical Laboratory
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics
Cardiology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

Paraproteins can cause a false elevation in plasma or serum inorganic phosphate when measured by the ammonium molybdate method. This needs to be distinguished from the hyperphosphatemia that occurs as a result of renal failure, hyperparathyroidism and tumor lysis. Recognition of the interference can prevent an unnecessary workup of the patient or failure to identify hypophosphatemia.

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