A number of factors may precipitate a painful neuropathy or other symptoms in a patient with porphyria. Reducing these factors can improve the quality of life of these patients.
(1) menstruation in women
(2) oral contraceptives
(3) occasionally pregnancy
Drugs (listing of unsafe drugs at the American Porphyria Foundation , www.enterprise.net):
(1) drugs that induced the hepatic P450 system
(2) other drugs considered unsafe (sulfonamides, etc.)
(4) ethanol ingestion
(1) dieting or fasting (high carbohydrate intake may reduce porphyrin excretion, so a low carbohydrate diet may precipitate attacks)
(1) emotional stress
(2) surgical procedures
(4) critical care
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Specialty: Endocrinology, Clinical Laboratory, Gastroenterology