Wang et al identified factors associated with cancer-related fatigue in patients with hematologic malignancies. These can help identify patient who may require closer monitoring and intervention to improve quality of life. The authors are from the University of Texas M.D. Anderson Cancer Center in Houston, Texas.


Cancer-related fatigue can result in decreases in:

(1) physical activity and exercise

(2) work capacity

(3) enjoyment of life

(4) mood

(5) relationships with others

(6) compliance with therapy


Factors associated with cancer-related fatigue:

(1) ECOG performance status 2 to 4

(2) pain requiring opioid therapy

(3) anemia with the need for blood transfusions

(4) nausea

(5) other gastrointestinal symptoms (anorexia, diarrhea, chewing and swallowing difficulties)

(6) sleep disturbances (insomnia, waking up during the night, waking up too early, waking unrefreshed)

(7) disease relapse or progression

(8) hypoalbuminemia

(9) inpatient status

(10) difficulty thinking clearly (cognitive impairments)



• Depression would also seem to correlate with fatigue and could explain some of the sleep disturbances.

• These factors should also apply to patients with Hodgkin's lymphoma.


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