Roelfsema et al evaluated a variety of factors affecting the patient following surgery on a pituitary adenoma. The authors are from Leiden University Medical Center in The Netherlands.
Patient selection: pituitary adenoma following surgical remission
Types of pituitary adenomas:
(1) acromegaly (growth hormone)
(2) Cushing's disease (ACTH)
(3) prolactinoma
(4) non-functioning
Factors impacting recurrence:
(1) The recurrence risk was highest with prolactinoma and lowest with nonfunctioning adenomas.
(2) The recurrence risk peaks at 1 to 5 years after surgery.
(3) For functioning adenomas the risk of recurrence was low if the post-operative serum hormone level was low.
The risk of impaired pituitary hypofunction is:
(1) highest with Cushing's disease.
(2) associated with more extensive surgery.
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