The extended release (ER) formulation of oxymorphone can provide effective long-term pain relief. However, toxic symptoms may develop if certain conditions occur.


Factors that may be associated with toxic symptoms:

(1) taking the drug with alcohol

(2) taking a broken, crushed or chewed tablet

(3) taking the dose with meals

(4) dissolving and injecting the drug

(5) moderate to severe renal dysfunction

(6) moderate to severe hepatic disease

(7) concomitant therapy with other CNS depressants

(8) taking a relatively high dose by a patient who is opioid naive

(9) taking an amount higher than the prescribed dose


A patient with one or more of these factors may experience serious complications.


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