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Factors Affecting the Decision to Use Denosumab in a Patient with Osteoporosis

Specialty:

Orthopedic Surgery, Sports Medicine & Rehabilitation
Endocrinology, Nutrition & Dermatology
Endocrinology, Nutrition & Dermatology

Objective:

ICD-10:

Description:

Denosumab (Prolia) is a therapy for osteoporosis that can be effective in selected patients with osteoporosis. Denosumab is a fully human antibody against RANKL (RANK Ligand, or Receptor Activator of Nuclear factor Kappa B Ligand). RANKL is produced by osteoblasts and is important in osteoclast differentiation. Its removal reduces osteoclastic activity and bone resorption.

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