Mannucci listed the dosage of Factor VIII-von Willebrand factor (vWF) concentrates need for a patient with von Willebrand's disease. The author is from the University of Milan.
20 to 30 IU/kg
30 to 50 IU/kg
once a day every 1-2 days
40 to 60 IU/kg
once a day
Target Factor VIII Coagulant Activity
Duration of Level
> 0.3 IU/mL
at least 12 hours
until healing complete
> 0.5 IU/mL
Since dosing after surgery is given until healing is complete, the least invasive method is preferred.
Knowing the half-life of the Factor VIII coagulant activity and von Willebrand Factor is important when planning a daily infusion, since the trough below the next dose has to exceed the minimum level for the period.
To read more or access our algorithms and calculators, please log in or register.
Specialty: Hematology Oncology, Clinical Laboratory, Clinical Laboratory, Clinical Pharmacology