A patient with a hereditary deficiency of prothrombin (Factor II) may develop a bleeding disorder depending on the extent of the deficiency.
Inheritance: autosomal, incompletely recessive
(1) easy bruisability
(3) soft tissue bleeding and/or hematomas
(4) bleeding after surgery or trauma
(5) menorrhagia (if female)
(6) post-partum bleeding (if female)
(7) rarely hemarthroses
(8) rarely intracerebral hemorrhage
Laboratory findings (assuming no factor replacement):
(1) prolonged PT
(2) prolonged aPTT
(3) normal thrombin time
(4) decreased prothrombin activity and/or antigen
(1) vitamin K deficiency
(2) other acquired prothrombin deficiencies
(3) Factor V or X deficiency
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Purpose: To evaluate a patient with a bleeding disorder for evidence of a hereditary deficiency of prothrombin (Factor II).
Specialty: Hematology Oncology, Clinical Laboratory
Objective: clinical diagnosis, including family history for genetics