Clinical Findings in Patient with Hereditary Deficiency of Factor II (Prothrombin)

 

Inheritance: autosomal, incompletely recessive

 

Clinical findings:

(1) easy bruisability

(2) epistaxis

(3) soft tissue bleeding and/or hematomas

(4) bleeding after surgery or trauma

(5) menorrhagia (if female)

(6) post-partum bleeding (if female)

(7) rarely hemarthroses

(8) rarely intracerebral hemorrhage

 

Laboratory findings (assuming no factor replacement):

(1) prolonged PT

(2) prolonged aPTT

(3) normal thrombin time

(4) decreased prothrombin activity and/or antigen

 

Differential diagnosis:

(1) vitamin K deficiency

(2) other acquired prothrombin deficiencies

(3) Factor V or X deficiency